Posts Tagged ‘hydroxyurea’

A recent argument in another sickle cell group inspired this post. Someone asked if Sickle Cell was a form of cancer. Most answers were no, including mine. I think since it’s now being treated with Hydroxyurea (which is used for cancer patients) they are thinking it’s a form of cancer. Hydroxyurea increases fetal hemoglobin production and slightly raises the total hemoglobin concentration in the body. Fetal hemoglobin reduces the chance that red blood cells will sickle in a person who has sickle cell disease which is to prevent to pain crisis and prevent frequent hospital stays. It’s use for SC warriors who have: Frequent painful events (at least three in a year), A history of recurrent acute chest syndrome, and Severe anemia.

A to Z List of Cancers – S

Salivary Gland Cancer
Childhood
Sarcoma
Ewing
Kaposi
        Osteosarcoma (Bone Cancer)
Rhabdomyosarcoma
Soft Tissue
Uterine
Sézary Syndrome
Skin Cancer
Childhood
Melanoma
Merkel Cell Carcinoma
Nonmelanoma
Small Cell Lung Cancer
Small Intestine Cancer
Soft Tissue Sarcoma
Squamous Cell Carcinoma – see Skin Cancer (Nonmelanoma)
        Childhood
Squamous Neck Cancer with Occult Primary, Metastatic
Stomach (Gastric) Cancer
Childhood

http://www.cancer.gov/cancertopics/types/alphalist/s

I don’t see Sickle Cell listed as a cancer or a form of cancer. Do you agree that sickle cell is NOT a form of cancer?

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Not many people are familiar with this medicine as treatment for Sickle Cell.

Let me first explain the uses of the medicine:

Hydroxyurea is used to treat skin cancer (melanoma), a cancer of the white blood cells called chronic myelocytic leukemia (CML), and metastatic cancer (cancer that has spread) of the ovaries. This medicine may also be given together with radiation treatment for head and neck cancer (primary squamous cell cancer).

Hydroxyurea is also used in adult patients with sickle cell anemia to prevent painful episodes and reduce the need for blood transfusions. It works by making the red blood cells more flexible.

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Although, Hydroxyurea was first synthesized in 1869 in Germany and became FDA approved in 1967 for the treatment of neoplastic diseases. It wasn’t until February 1998, hydroxyurea received a new indication, for the treatment of sickle cell disease. It is approved for use in reducing the frequency of painful crises and the need for blood transfusions in adult patients with recurrent moderate-to-severe painful crises (generally at least three during the preceding 12 months).

The efficacy of Hydroxyurea in the treatment of sickle cell disease is generally attributed to its ability to boost the levels of fetal hemoglobin. This lowers the concentration of Hb S within a cell resulting in less polymerization of the abnormal hemoglobin. However, the mechanisms by which it increases Hb F are unclear.

I’ve asked many carriers about the effects they’ve noticed in themselves or their children who are carries and I received different answers…….below

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